GB 16189-1996 Hygienic standard for isocyanate in workshop air

This standard specifies the maximum permissible concentration of Isopropylamine in workshop air and its monitoring and testing methods. This standard is applicable to all types of enterprises that produce and use Isopropylamine. GB 16189-1996 Hygienic standard for Isopropylamine in workshop air GB16189-1996 Standard download decompression password: www.bzxz.net

National Standard of the People's Republic of China
Health standard for kitazin-p in the air of workplace
Health standard for kitazin-p in the air of workplaceSubject content and scope of application
This standard specifies the maximum permissible concentration of kitazin-p in the air of workplace and its monitoring and inspection methods. This standard applies to all types of enterprises that produce and use kitazin-p. Hygiene requirements
The maximum permissible concentration of kitazin-p in the air of workplace is 1.0mg/m (skin). 3
Monitoring and inspection methods
The monitoring and inspection methods of this standard adopt gas chromatography, see Appendix A. Supervision and implementation
Health and epidemic prevention agencies at all levels are responsible for supervising the implementation of this standard. Approved by the State Administration of Technical Supervision on April 3, 1996 398
GB16189-1996
Implementation on September 1, 1996
A1 Principle
GB 16189—1996
Appendix A
Gas chromatography
(Supplement)
Isopropylamine in air is adsorbed on a silica gel tube, desorbed with acetone, separated on a 0V-17 chromatographic column, and detected with a flame photometric detector. Qualitative determination is based on retention time, and quantitative determination is based on peak height.
The detection limit of this method is 0.5ng.
A2 Apparatus
Gas chromatograph, flame photometric detector, 526nm phosphorus filter. Gas sampler. 5mL stoppered test tube. 10μL microinjector. Silicone sampling tube, glass tube inner diameter 4~~5mm, 600mg 40~~60 mesh silica gel is loaded in two sections, the front section is 5cm long, the back section is 1cm long, blocked with medical absorbent cotton, and sealed with plastic caps at both ends. A3 Reagent
A3.1 Chromosorb W-AW-DMCS carrier, 80~10o mesh. A3.20 V-17 Chromatographic stationary liquid.
A3.3 Isoblastine pure product (99.5%).
A3.4 Acetone.
A4 Sampling
At the sampling site, remove the plastic caps at both ends of the silicone tube, place it vertically, and sample at a speed of 200mL/min. After sampling, cover it with a plastic cap, take it back to the laboratory, and store it in a 4℃ refrigerator for analysis. According to the recommended maximum allowable concentration and the detection limit of this method, the minimum gas sampling volume is 4.
A5 Analysis steps
A5.1 Chromatographic conditions
a. Chromatographic column: glass column, 2m×3mm, 2%0V-17. Column temperature: 220℃. b.
Vaporization chamber temperature: 250℃.
Detection chamber temperature: about 140℃.
d. Carrier gas (nitrogen): 50mL/min.
A5.2 Standard curve drawing
Use an analytical balance to accurately weigh 10mg (about 10μL) of Isoblastine standard and dissolve it in acetone to the 10mL mark. This is the stock solution 1 ml, = 1 mg Isoblastine. Take the stock solution and dilute it with acetone to 1 mL = 100 μg standard application solution A, then take the standard application solution A and dilute it with acetone to 1ml, = 1μg standard application solution B. Take 2, 4, 6, 8, 10μL of application liquid B for injection, plot the net content of rice blast against the peak height, and draw a standard curve.
A5.3 Sample analysis
Pour the front and back sections of silica gel of the sampling tube into 5mL scaled stoppered test tubes respectively, put the cotton at the air inlet end of the sampling tube into the test tube of the front section, and the cotton in the middle and back of the tube into the test tube of the back section. Add 1-2mL acetone for desorption, shake vigorously for 1min (150 times), let it stand for 30 minutes, and then take 1μL for injection.
A6 Calculation
GB 16189--1996
Wu Zhong: X—-net concentration of rice blast in air, mg/m;--check the standard curve or calculate the total content of silica gel adsorption from the regression equation, ngV.--sampling volume under standard conditions, mL. A7 Precautions
A7.1 Ketones are volatile, and the standard solution is stored in a 4C refrigerator. The samples after desorption should also prevent the solvent from evaporating. A7.2 Samples should be analyzed in time. The sample tube is stored in a 4C refrigerator and can be stable for 5 days. A8 Experimental results and explanations of this method
A8.1 The standard curve range is 010ng, and the regression equation is y=4.3333r-1.2781r=0.9961. (Al)
A8.2 Precision Take 5 concentrations of the standard curve, and the corresponding coefficients of variation for each determination are 5.40%, 4.15%, 4.20%, 5.61% and 2.88%.
A8.3 Accuracy Take 6 samples for spiked determination, the sample concentration is 0.182~0.582ug/mL desorption solution, the spiked concentration is 1μg/ml, and the average spiked recovery is 95.17%. A8.4 The determination of Isoblastine by this method can be separated from other substances in the workshop, and the retention time of the standard sample is used for qualitative analysis, as shown in the chromatogram of Figure A1. 3'50
Time, min
Figure A1 Chromatogram of Isoblastinebzxz.net
1-Acetone; 2-Isoblastine Standard
A8.5 Detection Limit
Under the conditions of this method, the chromatographic baseline is flat and has no noise peaks, and there is no peak in the blank test. It is now proposed that 0.5ng of Isoblastine corresponding to a peak height of 2mm is the detection limit of this method.
A8.6 Blank Test Four sampling tubes, each with 1ug of standard, two of which collect 20L of fresh air and then analyze, the peak height is 5.125mm, the other two are directly analyzed, the peak height is 5.25mm, and the recovery rate is 97.62%. o
Additional Notes:
GB16189
This standard is proposed by the Ministry of Health of the People's Republic of China. This standard was drafted by the Labor Hygiene Teaching and Research Section of the School of Public Health of Shanghai Medical University, the Labor Hygiene Section of Zhenjiang Municipal Health and Epidemic Prevention Station, and the Hygiene Section of Shanghai Pesticide Factory.
The main drafters of this standard are Lu Qiming and Ye Yanqing. This standard is interpreted by the Institute of Labor Hygiene and Occupational Diseases of the Chinese Academy of Preventive Medicine, the technical unit entrusted by the Ministry of Health.
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