GBZ 86-2002 Diagnostic criteria for occupational acute unsymmetrical dimethylhydrazine poisoning

This standard specifies the diagnostic criteria and treatment principles for occupational acute unsymmetrical dimethylhydrazine poisoning. This standard applies to the diagnosis and treatment of acute poisoning caused by exposure to unsymmetrical dimethylhydrazine in occupational activities. Non-occupational acute unsymmetrical dimethylhydrazine poisoning can also be implemented as a reference. GBZ 86-2002 Occupational acute unsymmetrical dimethylhydrazine poisoning diagnostic criteria GBZ86-2002 standard download decompression password: www.bzxz.net

ICS 13.100
National Occupational Health Standard of the People's Republic of China GBZ86—2002
Diagnostic Criteria of Occupational Acute 1,1-Dimethylhydrazine PoisoningPublished on April 8, 2002
Implemented on June 1, 2002
Ministry of Health of the People's Republic of China
Article 6.1 of this standard is recommended, and the rest are mandatory. This standard is formulated in accordance with the Law of the People's Republic of China on the Prevention and Control of Occupational Diseases. UDMH is an important chemical raw material for the national defense industry. Acute UDMH poisoning may occur in occupational activities involving UDMH. This standard is formulated to protect the health of those exposed to UDMH and effectively prevent and control acute UDMH poisoning
Appendix A of this standard is an informative appendix, and Appendix B is a normative appendix. This standard is proposed and managed by the Ministry of Health of the People's Republic of China. This standard was drafted by the Industrial Hygiene and Occupational Disease Prevention and Control Center of China Aerospace Science and Technology Corporation. The Academy of Military Medical Sciences and the 307th Hospital of the People's Liberation Army participated in the drafting.
This standard is interpreted by the Ministry of Health of the People's Republic of China. Diagnostic Standard for Occupational Acute Unsymmetrical Dimethylhydrazine Poisoning GBZ86-2002
Occupational acute unsymmetrical dimethylhydrazine poisoning is a disease caused by short-term exposure to a large amount of unsymmetrical dimethylhydrazine in occupational activities, with damage to the central nervous system as the main cause. It is often accompanied by liver damage. 1 Scope
This standard specifies the diagnostic criteria and treatment principles for occupational acute unsymmetrical dimethylhydrazine poisoning. This standard is applicable to the diagnosis and treatment of acute poisoning caused by exposure to unsymmetrical dimethylhydrazine in occupational activities. Non-occupational acute unsymmetrical dimethylhydrazine poisoning can also be implemented by reference. 2 Normative References
The clauses in the following documents become the clauses of this standard through reference in this standard. For any dated referenced document, all subsequent amendments (excluding errata) or revisions are not applicable to this standard. However, parties reaching an agreement based on this standard are encouraged to study whether the latest versions of these documents can be used. For any undated referenced document, the latest version shall apply to this standard.
GB/T16180
3 Diagnostic principles
Diagnostic criteria for occupational toxic liver disease
Evaluation of the degree of disability caused by work-related injuries and occupational diseases of employees Based on the occupational history of inhalation or skin contamination of a large amount of unsymmetrical dimethylhydrazine in a short period of time, combined with the clinical manifestations of central nervous system damage and liver damage, reference to on-site labor hygiene survey data, comprehensive analysis, and exclusion of similar diseases caused by other causes, a diagnosis can be made.
4 Contact reaction
One of the following conditions:
a) After exposure to unsymmetrical dimethylhydrazine, transient eye and upper respiratory tract irritation symptoms occur, followed by dizziness, headache, fatigue, nausea and other symptoms, and no positive findings in neurological examination. b) Skin contamination may cause burning sensation, local redness and swelling. 5 Diagnosis and grading standards
5.1 Mild poisoning Www.bzxZ.net
Symptoms include obvious dizziness, headache, fatigue, insomnia, nausea, vomiting, loss of appetite, and one of the following:
a) Excitement, irritability, limb twitching; b) Acute mild toxic liver disease.
5.2 Severe poisoning
Paroxysmal tonic spasm;
6 Treatment principles
6.1 Treatment principles
6.1.1 After unsymmetrical dimethylhydrazine poisoning, the person should quickly leave the scene, move to a place with fresh air, and take off the contaminated clothes. 6.1.2
When the body surface is contaminated with liquid unsymmetrical dimethylhydrazine, rinse it with clean water immediately. For poisoned patients, according to the severity of the disease, give the special antidote vitamin B6 for treatment. Symptomatic supportive treatment:
Correct acid-base balance and electrolyte disorders;
Hepatoprotective treatment.
6.2 Other treatments
Patients with acute mild poisoning usually recover within a few days and can resume their original work after recovery. Patients with severe poisoning can also recover completely after active treatment. After a few patients are rescued and escape danger, their symptoms in the recovery period are somewhat repeated. According to the examination results, they can be treated with reference to the relevant provisions of GB/T16180.
Instructions for the correct use of this standard
See Appendix A (Informative Appendix).
Appendix A
(Informative Appendix)
Instructions for the correct use of this standard
A.1 For those with small areas of skin contamination, 2.5% iodine can be used to scrub until the iodine does not fade. A.2 Limb convulsion in mild poisoning refers to a short-term limb spasm attack. The convulsion of the upper and lower limbs can be unilateral or bilateral, without consciousness disorder. The manifestations of paroxysmal tonic convulsions of severe poisoning are similar to those of grand mal epilepsy. A.3 After unsymmetrical dimethylhydrazine enters the human body, it combines with vitamin B6 and 5-pyridoxal phosphate to form hydrazine. Vitamin B6 and 5-pyridoxal phosphate are coenzymes of glutamate dehydroxylase and -aminobutyric acid transaminase. The decrease in the activity of these two enzymes in the brain can lead to a decrease in the production of -aminobutyric acid, which puts the central nervous system in an excited state and causes convulsions. Therefore, unsymmetrical dimethylhydrazine poisoning is often treated with a specific antidote, vitamin B6. A.4 The use of vitamin B can be based on the severity of the disease. First, intravenous injection of vitamin B6 1.0~5.0g, if the spasm does not stop, repeat intravenous injection of 0.5~1.0g, and then change to intravenous drip, 0.5g every 30min to 1h. The general dosage is 10g/d, and the maximum can be up to 35g/d. During the spasm, antispasmodics such as phenobarbital and diazepam can be used at the same time for better results. When hydrazine or monomethylhydrazine spasms occur, vitamin B6 can be used for treatment according to this plan.
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